Erscheinungsdatum: 23.08.2016, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: Diabetes & C-Peptide, Titelzusatz: Scientific and Clinical Aspects, Auflage: Softcover reprint of the original 1st ed. 2012, Redaktion: Sima, Anders A. F., Verlag: Humana Press // Humana Press Inc., Sprache: Englisch, Schlagworte: Klinische und Innere Medizin // Endokrinologie, Rubrik: Medizin // Andere Fachgebiete, Seiten: 184, Informationen: Paperback, Gewicht: 358 gr, Verkäufer: averdo
The prevalence of thyroid disease in patients with diabetes is significantly higher than that in the general population.This indicates a possible interplay between thyroid status and insulin sensitivity. Complex interplay between thyroid function and insulin resistance (IR) has been implicated in diabetic dyslipidemia. Homeostatic model assessment (HOMA) of -cell function and IR is a method for assessing -cell function and IR from basal glucose and insulin or C-peptide concentrations. The use of HOMA to estimate insulin sensitivity and -cell function helps to compare -cell function and insulin sensitivity In the light of the existing reports we decided to 1) evaluate the correlation between altered thyroid state and development of IR clinically, 2) to assess cell function and IR by HOMA-IR. Our study concluded that thyroid disorder, including both hypo- and hyper, have been associated with IR due to various mechanism like altered insulin secretion and lipid levels. Thus even subtle increase or decrease in the thyroid levels can lead to IR leading to risk of glucose related disorder like diabetes dyslipidemia.
The purpose of this study was to assess the level of fasting plasma glucose, zinc level, C-peptide level and HbA1c in type II diabetes mellitus (DM) population of Bangladesh and to correlate the values with several markers of zinc level. Since Zinc plays a clear role in the synthesis, storage and secretion of insulin as well as conformational integrity of insulin in hexameric form, the decreased Zn, which affects the ability of the islet cell to produce and secrete insulin, might then compound the problem, particularly in Type II diabetes.This study was conducted in Nutrition lab, Department of Biochemistry & Molecular Biology, University of Dhaka. The Zinc level was very much low in type II diabetes patients than it was in the control group. C-peptide production was also very low in type II diabetes patients than it was in the control group.The subjects are categorized according to Control Group and Hyperglycemic Group and it was found that mean value of FPG, ABF and HbA1c were higher in hyperglycemic group than it was in the control group. In our study we found that serum zinc level was approximately 56 % lower in the diabetes group (p 0.001).